Process for the synthesis of glycosaminoglycans containing .alph

Details Process for the synthesis of glycosaminoglycans containing .alph Process for the synthesis of glycosaminoglycans containing .alph

1994-03-07

1995-04-25

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 21, 530322, 530345, C08B 3700

Patent

active

054100399

ABSTRACT:
A process for the synthesis of glycosaminoglycans in which one of the .alpha.-L-iduronic-2-O-sulfate acid saccharide units, which is characteristic of glycosaminoglycans with heparin or heparan structure, has undergone a structural modification, entirely or in part, with transformation into .alpha.-L-galacturonic acid substituted in position 3 with nucleophilic groups, is described. The process is carried out by treating glycosaminoglycans having heparin or heparan structure with a nucleophilic reagent in alkaline solution.

REFERENCES:
patent: 4987223 (1991-01-01), Choay et al.
patent: 5010063 (1991-04-01), Piani et al.
patent: 5104860 (1992-04-01), Piani et al.
Gallagher J. T., Walker A. Molecular distinctions between heparan sulphate and heparin. Analysis of sulphation patterns indicates that heparan sulphate and heparin are separate families of N-sulphated polysaccharides. Biochem. J. 1985:230:665-74.
Turnbull, J. E., Gallagher J. T. Distribution of iduronate 2-sulphate residues in heparan sulphate. Evidence for an ordered polymeric structure. Biochem. J. 1991:273:553-559.
Lindahl U., Kjellen L. Heparin or Heparan Sulfate -What is the Difference? Thrombosis and Haemostasis-F. K. Schattauer Verlags-gesellschaft mbH(Stuttgart) 66(1)44-36 (1991).
Jaseja et al. Can. J. Chem. 1989, 67, 1449-1456.

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