Process for the synthesis of ganciclovir

Details Process for the synthesis of ganciclovir Process for the synthesis of ganciclovir

2006-07-18

2006-07-18

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

Reexamination Certificate

active

07078524

ABSTRACT:
The present invention relates to an industrial useful process for the synthesis of antiviral compound, ganciclovir which comprises dissolving a mixture containing N-7 and N-9 isomers of structural formulae, II and III, respectively:in a solvent or a mixture of solvents; separating the N-7 and N-9 isomers; and hydrolizing the N-9 isomer to obtain ganciclovir.

REFERENCES:
patent: 4199574 (1980-04-01), Schaeffer
patent: 4294831 (1981-10-01), Schaeffer
patent: 4355032 (1982-10-01), Verheyden et al.
patent: 4355034 (1982-10-01), Shen et al.
patent: 4816447 (1989-03-01), Ashton et al.
patent: 5565565 (1996-10-01), Lodewijk et al.
patent: 5583225 (1996-12-01), Chu et al.
patent: 5756737 (1998-05-01), Turchetta et al.
patent: 5792868 (1998-08-01), Izawa et al.
patent: 5821367 (1998-10-01), Kumar et al.
patent: 6043364 (2000-03-01), Kumar et al.
patent: 2005/0176956 (2005-08-01), Babu et al.
patent: 833006 (1976-03-01), None
patent: 532 878 (1992-08-01), None
patent: 806 425 (1997-11-01), None
patent: 976 751 (2000-02-01), None
patent: 59-80685 (1984-05-01), None
patent: 63-107982 (1988-05-01), None
patent: 157825 (1988-08-01), None
Matsumoto, et al., “A Convenient Synthesis of 9-(2-Hydroxyethoxymethyl)guanine (Acyclovir) and Related Compounds”. Chem. Pharm. Bull., 36 (3), pp. 1153-1157 (1988).
J.C. Martin, et al., “9-[(1,3-Dihydroxy-2-propowy)methyl]guanine: A New Potent and Selective Antiherpes Agent”. J. Med. Chem., 26, pp. 759-761 (1983).
Boryski, et al., “A Facile Synthesis of 9-(1,3-Dihydroxy-2-propoxymethyl) guanine (Ganciclovir) from Guanosine”. Synthesis. 1999, No. 4, pp. 625-628.
Field, et al. “9-{[2-Hydroxy-1-(hydromethyl)ethoxy]methyl} guanine: A selective inhibitor of herpes group virus replication”. Proc. Natl. Acad. Sci. Jul. 1983, vol. 80, pp. 4139-4143.

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