Process for the synthesis of distamycin and derivatives...

Details Process for the synthesis of distamycin and derivatives... Process for the synthesis of distamycin and derivatives...

2004-05-28

2008-11-11

Russel, Jeffrey Edwin (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

C548S530000, C548S532000

Reexamination Certificate

active

07449547

ABSTRACT:
A process for the total synthesis of Distamycin, and synthetic poly-(4 aminopyrrole-2-carboxamide) congeners thereof, using 1-methyl-4-forinylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate, is provided. The process finds application for both in solution and solid support synthetic technologies.

REFERENCES:
patent: 5670534 (1997-09-01), Animati et al.
Bialer et al: “A Total Synthesis of Distamycin A, an Antiviral Antibiotic” Tetrahedron, vol. 34, 1978, pp. 2389-2391, XP002293994 cited in the application scheme, p. 2390.
Grehn et al: “Novel Efficient Totel Synthesis of Antiviral Antibiotic Distamycin A” Journal of Organic Chemistry vol. 46, 1981 pp. 3492-3497 XP002293995 scheme I p. 3494.

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