Process for the synthesis of cyclopentene derivatives of purines

Details Process for the synthesis of cyclopentene derivatives of purines Process for the synthesis of cyclopentene derivatives of purines

1990-04-06

1992-09-01

Rivers, Diana G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544277, 556418, C07D47318, C07D47340

Patent

active

051440342

ABSTRACT:
This invention relates to a new process for preparing certain optically active cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1'R-cis isomer of carbovir, (1'R-cis)-2-amino-1,9-dihydro-9[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-p urin-6-one, an antiviral agent.

REFERENCES:
patent: 4916224 (1990-04-01), Vince et al.
patent: 4931559 (1990-06-01), Vince et al.
patent: 4950758 (1990-08-01), Vince et al.
March, J., Advanced Organic Chemistry, 3rd Ed., Chap. 4, John Wiley & Sons, New York, NY (1985).
Vince, R., et al., Biochem. Biophys. Res. Commun. 156 (2) 1046 (1988).
Trost, et al., J. Am. Chem. Soc., 110, 621 (1988).
Synthesis, Sugai, T., et al., 19-22 (1988).
Barrett, et al., J. Organic Chemistry, vol. 51, No. 7, pp. 1012-1015 (1986).
Williams, et al., Tetrahedron Letters, vol. 26(51) pp. 6269-6271 (1985).
Peel, et al., Journal of Organic Chemistry, vol. 56, No. 16, pp. 4990-4993 (1991).
McMurry, et al., J. Org. Chem., vol. 39, No. 2, 259-260 (1974).

Affiliated with

Also associated with

Rating

Process for the synthesis of cyclopentene derivatives of purines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the synthesis of cyclopentene derivatives of purines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthesis of cyclopentene derivatives of purines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-768758