Process for the synthesis of cefaclor

Details Process for the synthesis of cefaclor Process for the synthesis of cefaclor

2005-12-23

2011-12-06

Hanley, Susan (Department: 1653)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

C435S041000, C435S047000

Reexamination Certificate

active

08071330

ABSTRACT:
The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D-phenylglycine in activated form (PGa) in the presence of an enzyme in a reaction mixture to form cefaclor, wherein at least part of 7-ACCA and/or PGa are added to the reaction mixture during the course of the reaction. The invention also relates to an aqueous mixture comprising an amount of cefaclor of >10 (w/w) %, an amount of 7-amino-3-chloro cephalosporanic acid of <2 (w/w) %, and an amount of D-phenyl glycine of <2 (w/w) % and a process for the recovery of cefaclor from this aqueous mixture. The invention also relates to cefaclor in crystal form having an absorbance at 400 nm (A400) of less than 0.250.

REFERENCES:
patent: 6287799 (2001-09-01), Van Dooren et al.
patent: 0 730 035 (1996-09-01), None
patent: 98/20120 (1998-05-01), None
patent: 03/055998 (2003-07-01), None
International Search Report for PCT/EP2005/057155 mail Feb. 22, 2007.

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