Process for the synthesis of amikacin

Details Process for the synthesis of amikacin Process for the synthesis of amikacin

1992-02-14

1998-06-09

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 137, 536 185, C07H 100

Patent

active

057635870

ABSTRACT:
In the synthesis of amikacin, having the formula: ##STR1## by acylation of a diprotected derivative of kanamycin A with a reactive derivative of L-(-)-4-amino-2-hydroxybutyric acid, the selection of the reaction solvent and of the pH conditions permit the industrial economically and the synthesis yield to be improved.

REFERENCES:
patent: 4136254 (1979-01-01), Nagabhushan et al.
patent: 4504472 (1985-03-01), Takaya et al.
patent: 4547492 (1985-10-01), Umezawa et al.
Wright et al, Journal of Antibiotics, Jul. 1976 pp. 714-719.

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