Process for the synthesis of 5-[(substituted amino]-8-[phenyl or

Details Process for the synthesis of 5-[(substituted amino]-8-[phenyl or Process for the synthesis of 5-[(substituted amino]-8-[phenyl or

1993-01-27

1993-09-21

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544251, C07D48704, C07D48716

Patent

active

052470865

ABSTRACT:
A novel process for producing 5-[(substituted)amino]-8-[phenyl or substituted-phenyl]-3H,6H-1,4,5a,8a-tetraazaace-naphthylen-3-ones of the formula: ##STR1## Where R.sub.1, R.sub.2 and R.sub.3 are defined in the specification by reacting a 4,5-dihydro-7-[phenyl or substituted phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide with carbon disulfide and a suitable base and a lower alkyl iodide to give a 5-(lower alkylthio)-8-[phenyl or substituted phenyl]-3H,6H-1,4,5a,8a-tetraazaacenaphthylen-3-one which is further reacted with an amine of the formula: ##STR2## to give the desired compounds is disclosed as well as 5-(loweralkylthio)-8-phenyl-3H,6H,1,4,5a,8a-tetra azaacenaphthylen-3-ones useful as intermediates in the process.

REFERENCES:
patent: 4916137 (1990-04-01), Epstein et al.

Affiliated with

Also associated with

Rating

Process for the synthesis of 5-[(substituted amino]-8-[phenyl or does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the synthesis of 5-[(substituted amino]-8-[phenyl or, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthesis of 5-[(substituted amino]-8-[phenyl or will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1051486