Process for the synthesis of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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Reexamination Certificate

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07928223

ABSTRACT:
Process for the synthesis of the compound of formula (I):Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

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Bomhard, A., et al., “Specific bradycardics agents. 2. heteroaromatic modification in the side chain of specific bradycardics benzazepinones: chemistry, pharmacology and structure-activity relationships” Journal of Medicinal Chemistry, vol. 34, p. 942-947, Jan. 1991.
Reffen, M., et al., “Specific Bradycardic agents. 1. chemistry, pharmacology and structure-activity relationships of substituted benzazepinones, a new clas of compounds exerting antiischemic properties” Journal of Medicinal Chemistry, vol. 33, No. 5, p. 1497-1504, May 1, 1990.
French Preliminary Search Report for FR0803452 of Feb. 19, 2009.
March, J.;Advanced Organic Chemistry, Fourth Edition, 1992, 400-401 and 437-438.

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