Process for the synthesis of...

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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Reexamination Certificate

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10358847

ABSTRACT:
The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine.

REFERENCES:
patent: 6002008 (1999-12-01), Wissner et al.
patent: WO 01/68186 (2001-09-01), None
Wissner et al. Journal of Medicinal Chemistry, 2003, vol. 46, p. 49-63.
A. Ono inChem. Ind. (London), 4, 130, 1982.
C.K. Lee, et al, J.Org. Chem., 1989, 54, 3744-3747.
Richard C. Larock,Comprehensive Organic Transformations, A Guide to Functional Group Preparations, VCH Publishers, New York, 1989, 823.

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