Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
2006-06-20
2006-06-20
Kifle, Bruck (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
active
07064200
ABSTRACT:
Process for the synthesis of compounds of formula (I):wherein R1and R2, which may be the same or different, each represent a linear or branched (C1–C8)alkoxy group or form, together with the carbon atom carrying them, a 1,3-dioxane, 1,3-dioxolane or 1,3-dioxepane ring.Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.
REFERENCES:
patent: 0204349 (1986-12-01), None
patent: 0534859 (2003-03-01), None
French Search Report for French Application No. 04.03828, Dec. 16, 2004.
European Search Report for European Application No. 05290383, Jul. 7, 2005.
Bomhard, et al.,J. Med. Chem., 1991, 34, 942-947.
Reiffen, et al.,J. Med. Chem., 1990, 33, 1496-1504.
Brigot Daniel
Lecouve Jean-Pierre
Lerestif Jean-Michel
Souvie Jean-Claude
Hueschen and Sage
Kifle Bruck
Les Laboratoires Servier
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