Process for the synthesis of 2-amino-3,5-dihydro-7-substituted-4

Details Process for the synthesis of 2-amino-3,5-dihydro-7-substituted-4 Process for the synthesis of 2-amino-3,5-dihydro-7-substituted-4

1993-12-15

1995-01-31

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D48704, C07B 3100

Patent

active

053860314

ABSTRACT:
An improved process for the preparation of 2-amino-3,5-dihydro-7-substituted-4H-pyrrolo[3,2-d]pyrimidin-4-ones is described wherein 2,6-diamino-3,5-dihydro-7-substituted-4H-pyrrolo[3,2-d]pyrimidin-4-one is converted to a diazonium salt which is subsequently catalytically hydrogenated to the desired compound, as well as valuable intermediates used in the process.

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patent: 5061707 (1991-10-01), Kostlan et al.
patent: 5281708 (1994-01-01), Josyula et al.
Journal of Medicinal Chemistry, 36:55-69 (1993) Montgomery J. A. et al.
Journal Medicinal Chemistry, 36: 1847-1854 (1993) Secrist III J. A., et al.
Journal Organic Chemistry, 36:723 (1971) Church, R. F. R., et al.

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