Process for the sterilization of biological compositions using U

Details Process for the sterilization of biological compositions using U Process for the sterilization of biological compositions using U

1996-10-03

1998-08-04

Weber, Jon P.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

4351731, 4351733, 435236, 424 9321, 424 9372, A01N 102, A01N 6300, C12N 1300, C12N 704

Patent

active

057891508

ABSTRACT:
An improvement in a process for inactivating extracellular and intracellular viruses in a platelet containing composition is presented. The improvement in the process comprises adding a sensitizer to the platelet containing composition and irradiating the composition containing the sensitizer with UVA1 in the absence of UVA2 for a period of time sufficient to inactivate the viruses while retaining the functionality of the platelet containing composition. A quencher or mixture of quenchers of type I and type II photodynamic reactions may be advantageously added to the composition prior to irradiation.

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