Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1994-12-23
1999-11-09
Wityshyn, Michael G.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
4351731, 4351733, 435236, 424 90, C12Q 100, C12N 1300
Patent
active
059811633
ABSTRACT:
The present invention concerns the product produced by inactivating extracellular or intracellular pathogenic virus in a biological composition without incurring substantial disruption or inactivation of cells and without significant loss of labile proteins or other valuable biological components also contained therein, the inactivation process comprising subjecting said composition to a virucidally effective amount of irradiation in the presence of (a) a mixture of a compound that quenches type I photodynamic reactions and a compound that quenches type II photodynamic reactions or (b) a bifunctional compound that is capable of quenching both type I and type II reactions, to thereby inactivate said virus while retaining functionality of said composition. The composition is advantageously subjected to the irradiation and the mixture of compounds or bifunctional compound in the presence of an irradiation sensitizer. Moreover, the process can be advantageously combined with a different virucidal method to enhance virus inactivation.
REFERENCES:
patent: 4008136 (1977-02-01), Williams et al.
patent: 4049798 (1977-09-01), Bottomley et al.
patent: 4530924 (1985-07-01), Polony et al.
patent: 4693981 (1987-09-01), Wiesehahn et al.
patent: 4727027 (1988-02-01), Wiesehahn et al.
patent: 4748120 (1988-05-01), Wiesehahn
patent: 4775625 (1988-10-01), Sieber
patent: 4791062 (1988-12-01), Wiesehahn et al.
patent: 4878891 (1989-11-01), Judy et al.
patent: 4935498 (1990-06-01), Sessler et al.
patent: 5032580 (1991-07-01), Watanabe et al.
patent: 5120649 (1992-06-01), Horowitz
patent: 5211944 (1993-05-01), Tempesta
patent: 5232844 (1993-08-01), Horowitz et al.
Prince, A.M., Horowitz, B., Horowitz, M.S. and Zang, E., 1987, "The Development of Virus-Free Labile Blood Derivatives--A Review", Eur. J. Epidemiol., 3, 103-118.
Mannucci, P.M. and Colombo, M., 1988, "Virucidal Treatment of Clotting Factor Concentrates", The Lancet, 782-785.
Rosenthal, I. and Ben-Hur, E., 1989, "Phthalocyanines in Photobiology", pp. 393-425, in Lezhoff, C.C. and Lever, A.B.P. (Eds), Phthalocyanines, VCH Publishers, Inc., New York, U.S.A.
Rosenthal, I. and Ben-Hur, E., 1986, "Photohemolysis of Human Erythrocytes Induced by Aluminum Phthalocyanine Tetrasulfonate", Cancer Lett., 30, 321-327.
Sonoda, Krishna and Riesz, 1987, "The Role of Singlet Oxygen in the Photohemolysis of Red Blood Cells Sensitized by Phthalocyanine", Photochem. Photobiol., 46, 625-631.
Cole, M., Stromberg, R., Friedman, L., Benade, L. and Shumaker, J., 1989, "Photochemical Inactivation of Virus in Red Cells", Transfusion, 29, Supp:42s Abs.
Prodouz, K.N., 1989, "Effect of Merocyanine 540 on Platelet Function and Reduction of its Antiviral Activity by Albumin", Transfusion, 29, Supp:42s Abs.
Moroff, G., Benade, L.E., Dabay, M., George, V.M., Shumaker, J. and Dodd, R.Y., 1989, "Use of Photochemical Procedures to Inactivate Viruses in Platelet Suspensions", Transfusion, 29, Supp: S15 Abs.
Matthews, J.T., Newman, J.T., Sogandares-Bernal, F., et al., 1988, "Photodynamic Therapy of Viral Contaminants with Potential for Blood Banking Applications", Transfusion, 28, 81-83.
Lin, L., Wiesehahn, G.P., Morel, P.A. and Corash, J., 1989, "Use of 8-Methoxypsoralen and Long-wavelength Ultraviolet Radiation for Decontamination of Platelet Concentrates", Blood, 74, 517-525.
Horowitz, U.S. Pat. application Ser. No. 07/279,179 filed Dec. 2, 1988 is now U.S. issued Patent #5,055,485.
Williams, B., et al., 1988, Blood, 72, Suppl:287a.
Prodouz, K.N., Fratantoni, J.C., Boone, J.E. and Bonner, R.F., 1987, "Use of Laser-UV for Inactivation of Virus in Blood Products", Blood, 70, 589-592.
Hartman, F.W., Mangun, G.H., Feeley, N. and Jackson, E., 1949, "On the Chemical Sterilization of Blood and Blood Products", Proc. Soc. Exp. Biol. Med., 70, 248-254.
LoGrippo, G.A., 1959, "Investigations of the Use of Beta-Propiolactone in Virus Inactivation", Ann NY Acad. Sci., 83, 578-594.
Spikes, J., 1986, Phthalocyanines as Photosensitizers in Biological Systems and for the Photodynamic Therapy of Tumors, Photochemistry and Photobiology, 43,691-699.
Ben-Hur, E. and Rosenthal, I., 1989, "The Phthalocyanines: A New Class of Mammalian Cell Photosensitizers with a Potential for Cancer Phototherapy", Int. J. Radiat. Biol., 47, 145-147.
Prince, A.M., Stephen, W., Bortman, B. and van den Ende, M.C., 1980, "Evaluation of the Effect of Beta-Propiolactone/Ultrtaviolet Irradiation (BPL/UV) Treatment of Source Plasma on Hepatitis Transmission by Factor IX Complex in Chimpanzees", Thrombosis and Hemostasis, 44, 138-142.
Horowitz, B., Wiebe, M., Lippin, A. and Stryker, M.H., 1985, "Inactivation of Viruses in Labile Blood Derivatives", Transfusion, 25, 516-522.
Prince, A.M., Pascual, D., Kosolapov, L.B., et al., 1987, "Prevalence, Clinical Significance, and Strain Specificity of Neutralizing Antibody to the Human Immunodeficiency Virus", The Journal of Infectious Diseases, 156, 268-272.
Prince, A.M., Horowitz, B., Baker, L., et al., 1988, "Failure of an HIV Immune Globulin to Protect Chimpanzees Against Experimental Challenge with HIV", Proc. Natl. Acad. Sci. U.S.A., 85, 6944-6948.
O'Brien, J.M., Montgomery, R.R., Burns, W.H., Gaffney, D.K. and Sieber, F., 1990, "Evaluation of Merocyanine 540-Sensitized Photoirradiation as a Means to Inactivate Enveloped Viruses in Blood Products", J. Lab. Clin. Med., 116, 439-447.
Gaffney, D.K., O'Brien, J.M. and Sieber, F., 1991, "Modulation by Thiols of the Merocyanine 540-Seensitized Photolysis of Leukemia Cells, Red Cells, and Herpes Simplex Virus Type I", Photochem. and Photobiol., 53, 85-92.
Chanh, T.C., et al., 1989, "Photodynamic Inactivation of Simian Immunodeficiency Virus", J. Virol. Meth., 26, 125-132.
Lytle, C.D., et al., 1989, "Inactivation and Mutagenesis of Herpes Virus by Photodynamic Treatment with Therapeutic Dyes", Photochem. and Photobiol., 50, 367-371.
Sessler, J.L., Hemmi, G.W. and Murai, T., PCT Publication # WO 90/10633. (cover page and claims).
Horowitz, et al., 1991, "Inactivation of Viruses in Blood with Aluminum Phthalocyanine Derivatives", Transfusion, 31, 102-108.
Morgan et al. (1989) Br. J. lancer, 59(3), 366-70 (Abstract).
Snipes et al. (1977) Radiat. Res., 70(3), 667, conference.
J. Morgan, A. G. Gray & E. R. Huehns, "Phthalocyanine Photosensitizer Mediated Viral Inactivation in Blood".
H. S. Neyndorff, et al. "Development of a Model to Demonstrate Photosensitizer Mediated Viral Inactivation in Blood".
Sonada et al, (1987) Photochem. Photobiol., 46(5), 625-631.
Rosenthal et al, (1989) in "Phthalocyanines", pp. 397-425, Lezhoff et al., Eds., VCH Publishers, Inc., New York.
Chin Sing N.
Horowitz Bernard
Margolis-Nunno Henrietta
Williams Bolanle
New York Blood Center Inc.
Weber Jon P.
Wityshyn Michael G.
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