Process for the sterilization of biological compositions and the

Details Process for the sterilization of biological compositions and the Process for the sterilization of biological compositions and the

1998-08-04

2000-07-11

Weber, Jon P.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4351731, 435236, 424 9372, C12N 1300, C12N 704, A01N 6300

Patent

active

060871415

ABSTRACT:
The present invention concerns a process for inactivating extracellular and intracellular virus in a biological composition without incurring substantial disruption or inactivation thereof, said process comprising subjecting said composition to a virucidally effective amount of UVA1 irradiation substantially in the absence of UVA2 irradition for a period of time sufficient to thereby inactivate said virus while retaining functionality of said composition. The biological composition is advantageously a product that contains red blood cells or platelets. The process is advantageously carried out in the presence of an irradiation sensitizer compound and/or a quencher. The present invention also concerns the product substantially identical to that produced bythe inventive process.

REFERENCES:
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patent: 5232844 (1993-08-01), Horowitz et al.
patent: 5658722 (1997-08-01), Margolis-Nunno et al.
patent: 5789150 (1998-08-01), Margolis-Nunno et al.
Beer et al., Photochem. Photobiol., 59(6), "Reassessment of the Differential Effects of Ultraviolet and Ionizing Radiation on HIV Promoter--The Use of Cell-Survival as the Basis for Comparisons", pp. 643-649, 1994.
Keeton et al., Biological Science, 4th Ed., W.W. Norton & Co., New York, p. 346, 1986.
Guttman, Dermatology Times, UVA-Induced Anuclear Damage Seen in Mammalian Blood Cells, p. 64, full text from PROMT, Nov. 1991.
Lin et al., Blood, 74, "Use of 8-Methoxypsoralen and Long-Wavelength Ultraviolet Radiation for Decontaminationg of Platelet Concentrates", pp. 517-525, 1989.

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