Process for the stereospecific synthesis of leukotriene B.sub.4

Details Process for the stereospecific synthesis of leukotriene B.sub.4 Process for the stereospecific synthesis of leukotriene B.sub.4

1994-05-31

1995-07-18

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554127, 554214, 554126, 554150, 554165, 554166, 554196, 554219, 560174, 560177, 560201, 560205, C07C 6966, C07C 6973

Patent

active

054342813

ABSTRACT:
Process for the stereospecific synthesis of leukotriene B.sub.4 (LTB.sub.4) of 6Z, 8E, 10E configuration of formula ##STR1## in which a dibenzoate triether is prepared which is subjected to a reductive elimination according to the diagram ##STR2## so as to obtain a triether which is converted in order to obtain the leukotriene B.sub.4.

REFERENCES:
patent: 4559310 (1985-12-01), Cantor et al.
patent: 4931444 (1990-06-01), Van Wauwe et al.
patent: 5185363 (1993-02-01), Brooks et al.
patent: 5210208 (1993-05-01), Huang et al.
patent: 5232948 (1993-08-01), Huang et al.
patent: 5292907 (1994-03-01), Maignan et al.
patent: 5366982 (1994-11-01), Dereu et al.
Lewis et al, "Functional Characterization of Synthetic Leukotriene B and Its Stereochemical Isomers", the Journal of Experimental Medicine, vol. 154, No. 4, 1981, pp. 1243-1248.

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