Process for the stereospecific synthesis of indole derivatives

Details Process for the stereospecific synthesis of indole derivatives Process for the stereospecific synthesis of indole derivatives

1987-06-29

1989-02-21

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548231, 548507, 548467, C07B 5300, C07D20916, C07D40312, C07D40512

Patent

active

048066559

ABSTRACT:
The present invention relates to a process for the stereo-specific synthesis of indole derivatives of formula: ##STR1## which consists in using 3-tosyloxy-1,2-O-isopropylidenepropane-1,2-diol (II) in an optically pure form in order to introduce the asymetric carbon C* of compound (I). Compound (II) is condensed with a suitable primary amine in order to prepare an oxazolidinone and condensation with a suitable phenol, and the oxazolidinone ring is then opened to form an indole compound (I).

REFERENCES:
patent: 4234595 (1980-01-01), Kreighbaum
patent: 4404217 (1987-09-01), Demarne
patent: 4510315 (1985-04-01), Demarne
patent: 4522824 (1985-06-01), Wagnon
Schwender, J. Med Chem 13, 634 (1970).

Affiliated with

Also associated with

Rating

Process for the stereospecific synthesis of indole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the stereospecific synthesis of indole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the stereospecific synthesis of indole derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1523178