Process for the solid phase synthesis of peptides which contain

Details Process for the solid phase synthesis of peptides which contain Process for the solid phase synthesis of peptides which contain

1987-11-24

1988-09-06

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

530327, 530328, A61K 3702

Patent

active

047694459

ABSTRACT:
Peptides and Peptide amides such as cholecystokinin (CCK-8) are synthesized in improved yields and purity by a solid phase process. The requisite protected peptide is elaborated and sulfated on a solid support, deprotected, and cleaved from the solid support to give the total synthesis of CCK-8 on a solid support. Thereafter, the peptide is purified in a single step by ion exchange chromatography to provide analytically pure CCK-8.

REFERENCES:
patent: 3038908 (1962-06-01), Beereloom
patent: 3579494 (1971-05-01), Ondetti et al.
patent: 3705140 (1972-12-01), Bernardi et al.
patent: 3714140 (1973-01-01), Sipos
patent: 3723406 (1973-03-01), Ondetti et al.
patent: 3778429 (1973-12-01), Ondetti et al.
patent: 3839315 (1974-10-01), Ondetti et al.
patent: 3892726 (1975-07-01), Ondetti et al.
patent: 4076913 (1978-02-01), Walker et al.
patent: 4102878 (1978-07-01), Penke et al.
patent: 4330466 (1982-05-01), Yanaihara et al.
patent: 4490364 (1984-12-01), Rivier et al.
Ondetti et al., Synthesis of Cholecystokinin-Pancreozymin. I, The C. Terminal Do Decapeptide, J.A.C.S., 92, pp. 195-199, (1970).
Pluscec et al., Synthesis of Analogs of the C-Terminal Octapeptide of Cholecystokinin-Pancreozymin Structure-Activity Relationship, J. Med. Chem. 13, pp. 349-352, (1970).
Gandreau et al., Solid-Phase Synthesis of COOH-Terminal Fragments of Cholecystokinin, Peptides, Rich & Gross Eds., pp. 193-195, (1981).
Crawley et al., The Role of Central and Peripheral Cholecystokinin in Mediating Appetitive Behaviors, Peptides, 3, pp. 535-538, (1982).
Penke et al., New Synthetic Approach to Peptide Sulfate Esters Syntesis and Biological Activities of CCK Analogs Abstr. Book for eighth American Peptide Symposium, p. 45, May 22-23, (1983).
Barany et al., Solid-Phase Peptide Synthesis, the Peptides Analysis, Synthesis, Biology, Chapter I, vol. 2, Gross & Melenhofer Ed., pp. 1-11, 65-67, 77-79.

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