Process for the solid phase synthesis of aldehyde, ketone, oxime

Details Process for the solid phase synthesis of aldehyde, ketone, oxime Process for the solid phase synthesis of aldehyde, ketone, oxime

1998-06-24

2000-10-17

Geist, Gary

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From carboxylic acid or derivative thereof

528405, 568323, 568386, 568407, 568436, 568483, C08G 6344, C07L 49115, C07C 4555

Patent

active

06133409&

ABSTRACT:
This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and .alpha.,.beta.-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

REFERENCES:
U.S. application No. 08/928,943, Morrissette et al.
Richter et al., A TFA-Cleveable Linking for Solid-Phase Synthesis of Hydroxamic Acids, Tetrahedron Letters, vol. 38, No. 3, pp. 321-322, 1997.
Wipf et al., Solid-Phase Synthesis of Peptide Mimetics with (E)-Alkene Amide Bond Replacements Derived from Alkenylaziridines, J. Org. Chem, 1997, 62, 1586-1587.
Fehrentz et al., Improved Solid Phase Synthesis of C-terminal Peptide Aldehydes, Tetrahedron Letters, vol. 36, No. 43, pp. 7871-7874, 1995.
Johnson et al., Solid Phase Synthesis of Alkenes Using The Horner-Wadsworth-Emmons Reaction and Monitoring by Gel Phase 31P NMR, Tetrahedron Letters, vol. 36, No. 51, pp. 9253-9256, 1995.
Dinh et al., Synthesis of Ketones and Aldehydes via Reactions of Weinreb-Type Amides on Solid Support, Tetrahedron Letters, vol. 37, No. 8, pp. 1161-1164, 1996.
Prasad et al., Solid-Phase Reagents for the Isolation and Protection of Carbonyl Compounds, J. Steroid Biochem, vol. 18, No. 3, pp. 257-261, 1983.
Salvino et al., Automated Parallel Synthesis of Olefins, ISLAR '97 Proceedings, pp. 99-106.

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