Process for the simultaneous production of artemisnin and essent

Details Process for the simultaneous production of artemisnin and essent Process for the simultaneous production of artemisnin and essent

1997-10-06

1999-09-21

Owens, Amelia

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

A61K 3578

Patent

active

059550848

ABSTRACT:
This invention relates to a novel process for the dual production of essential oil and artemisinin from the plant Artemisia annua, said process comprising extracting the plant with hexane, partitioning the hexane extract between hexane and acetonitrile, hydrodistillation of hexane residue and Marc to yield essential oil, further fractionation of acetonitrile solvent between hexane-benzene mixture to remove artemisinic acid, chromatographing of the acetonitrile phase to produce substantially pure artemisinin, the artemisinic acid is reduced to obtain dihydro artemisinic acid which is then oxidised in a single step to form artemisinin.

REFERENCES:
Woerdenbag et al., "Artemisinin, Related Sesquiterpenes, and Essential Oil in Artemisia annua During a Vegetation Period in Vietnam" Planta Med. 60:272-275 (1994).
Vonwiller et al., "An Improved Method for the Isolation of Qinghao (Artemisinie) Acid from Artemisia Annua" Planta Med. pp. 562-563 (1993).
Klayman et al., "Isolation of Artemisinin (Qinghaosu) from Artemisia Annua Growing in the United States" Journal of Natural Products 47:715-717 (1984).
Roth, "A Facile Semisynthesis of the Antimalarial Drug Qinghaosu" J. chimical Education 68:612 (1991).

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