Process for the separation of (S,S) diastereoisomers

Details Process for the separation of (S,S) diastereoisomers Process for the separation of (S,S) diastereoisomers

1983-10-06

1985-09-17

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562571, 562443, 560191, C07C10120

Patent

active

045422346

ABSTRACT:
The (S,S) optical isomer of a compound having the general formula ##STR1## wherein R and R.sub.1-5 are as defined herein, is recovered essentially free of the (R,S) and (S,R) isomers, by forming a solution of the esters of the (S,S) and the (R,S) and/or (S,R) isomers of said compound, selectively precipitating an acid salt (e.g. maleate) of the (S,S) ester from the solution, and treating the precipitate to form the desired free acid.

REFERENCES:
patent: 3887606 (1975-06-01), Phillipps et al.
patent: 3976680 (1976-08-01), Clark et al.
patent: 3983162 (1976-09-01), Schlatter
patent: 4344949 (1982-08-01), Hoefle et al.
Patchett et al., "A New Class of Angiotensin-Converting Enzyme Inhibitors", Nature, vol. 288, (Nov. 20, 1980), pp. 280-283.
Noller, Chemistry of Organic Compounds, 3rd Edition, p. 359, (W. B. Saunders Co., 1965).

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