Process for the separation of mixtures of insulin, insulin deriv

Details Process for the separation of mixtures of insulin, insulin deriv Process for the separation of mixtures of insulin, insulin deriv

1985-12-04

1987-06-30

Waddell, Frederick E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Insulin; related peptides

A61K 3726, C07K 740

Patent

active

046771921

ABSTRACT:
A method for separating insulin or certain insulin derivatives from mixtures containing the same by chromatography of the mixture on a column filled with silica gel having a particle size between 40 and 500 microns with an eluant mixture comprising chloroform, methanol, water and triethylamine.

REFERENCES:
Arh. Hig. Rada-Meniga et al., 14(1963), 165-169.
Pickart et al.-Prep. Biochem. 5, 397-412, 1975.
Chrambach et al., J. Biol. Chem., 235, 3478-3483, (1960).
Carpenter et al.,-Biochem. 2, 1272-1277, (1963).
"Bioresearch and Chromatography Products", Pierce Eurochemie, B.V. Rotterdam, p. 194.
"The Chemist's Companion", Wiley-Interscience, New York (1975), p. 370.
"Reagenzien Diagnostica Chemikalien", 1980, E. Merck, Darmstadt, pp. 328 & 358.
Porath et al., Biochim. Biophys. Acta 13, 268-277 (1954).
Organikum, VEB Deutscher Verlag der Wissenschaften, Berlin, 1973, 12th Ed., p. 79.

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