Process for the separation of L-leucine and L-isoleucine

Details Process for the separation of L-leucine and L-isoleucine Process for the separation of L-leucine and L-isoleucine

1987-03-31

1988-03-15

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560155, C07C 9912

Patent

active

047314761

ABSTRACT:
The invention relates to a process for the separation of L-leucine and L-isoleucine. The process is carried out by subjecting a mixture of leucine ester, and isoleucine ester, (or a mixture of leucine ester, isoleucine ester and valine ester) to an esterase catalyzed hydrolysis resulting in a selective hydrolysis of the leucine ester. The pure L-leucine can be isolated from the reaction mixture by first removing the non-hydrolyzed esters by extraction with an organic solvent and then crystallizing the L-leucine at its isoelectric point. The recovered L-iso-leucine ester is purified by distillation (if necessary), and hydrolyzed to yield pure crystalline L-isoleucine.

REFERENCES:
patent: 3960942 (1976-06-01), Hirsbrunner

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