Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1986-05-21
1988-04-05
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530383, 530413, 530415, 530417, 530811, 530813, 530815, 530816, 424 85, 424101, 525 541, 436532, 435181, 601N 3350, 601N 3000, A61M 136
Patent
active
047360194
ABSTRACT:
The process for the separation of antiVIII:C antibodies present in a liquid consists of contacting said liquid with a solid support constituted by a polymer or a copolymer having in its chain substitutable groups, whereof at least part is substituted by groups having an affinity for antiVIII:C antibodies and a selectivity for antiVIII:C antibodies compared with other immunoglobulins and then separating the liquid from the support on which have been adsorbed the antiVIII:C antibodies.
Preferably use is made of polystyrene, to which have been fixed groups --SO.sub.3 Na and --SO.sub.2 Glu, --SO.sub.2 Threo, --SO.sub.2 OHPro or SO.sub.2 Lys. These supports can be used for ex-vivo purification in the column of the blood plasma of a type A hemophiliac.
REFERENCES:
patent: 3969284 (1976-07-01), Gray
patent: 4569967 (1986-02-01), Kornreich et al.
Nilsson et al, "A Procedure for Removing High Titer Antibodies by Extracorporeal Protein-A-Sepharose Adsorption in Hemophilia! Substitution Therapy and Surgery in a Patient with Hemophilia B and Antibodies" Blood, vol. 58, No. 1 (Jul.) 1981, pp. 38-44.
Chemical Abstracts, vol. 91, ref 54 297z(1979).
Chemical Abstracts, vol. 101, ref 52 882n(1984).
Bellattar Noureddine
Gulino Danielle
Jozefonvicz Jacqueline
Commissariat a l''Energie Atomique
Nutter Nathan M.
Phillips Delbert R.
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