Process for the separation of antibiotic macrolides

Details Process for the separation of antibiotic macrolides Process for the separation of antibiotic macrolides

1977-10-03

1979-07-03

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435119, 424181, C07H 1708

Patent

active

041600835

ABSTRACT:
This case relates to a novel process which aids in the isolation and purification of novel compounds which are produced by the microorganism, Streptomyces avermitilis. The process described herein utilizes a hydroxypropyl Sephadex column chromatographic step in the isolation of the compounds from broth. The compounds which are isolated and purified are described generically s C-076 and have significant parasiticidal activity.

REFERENCES:
patent: 3950360 (1976-04-01), Aoki
Mishima et al. Tetrahedron Letters 10 p. 711-714, 1975.
Journal of Antibiotics 29(6) Jun. 1976, pp. 76-36 to 76-42 and 76-14 to 76-16.

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