Process for the selective preparation of isosorbide-2-mononitrat

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D49304

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active

047772743

ABSTRACT:
A process for the preparation of isosorbide-2-mononitrate (I) ##STR1## from isosorbide-2,5-dinitrate (II) ##STR2## The isosorbide-2,5-dinitrate (II) is treated, in a reaction medium consisting of an aqueous organic solvent, with salts of metals of low oxidation state.
Isosorbide-2-mononitrate (I) is obtained with high selectivity.

REFERENCES:
patent: 4381400 (1983-04-01), Emeury et al.
patent: 4713466 (1987-12-01), De Lucchi et al.
Moraghan et al., Chemical Abstracts 86:188400h.

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