Process for the selective formation of disulfide bridges in poly

Details Process for the selective formation of disulfide bridges in poly Process for the selective formation of disulfide bridges in poly

1980-06-09

1982-09-28

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125K, C07C10352

Patent

active

043517641

ABSTRACT:
A process for the selective formation of at least two disulfide bridges in a polypeptide which process comprises treating a polypeptide starting material carrying at least two SH-groups to mask at least one of said SH-groups with a p-methoxybenzyl protective group and to mask at least one of the SH-groups with an acetamido methyl protective group, then splitting-off said p-methoxybenzyl protective group with pyridine-polyhydrogen fluoride in the presence of anisol, and then treating with iodine in an acid solution to produce said disulfide bridge-containing polypeptide.

REFERENCES:
patent: B471617 (1976-02-01), Kamber et al.
patent: 3883500 (1975-05-01), Geiger et al.
patent: 4029642 (1977-06-01), Obermeier

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