Process for the selective extracorporeal precipitation of low-de

Details Process for the selective extracorporeal precipitation of low-de Process for the selective extracorporeal precipitation of low-de

1988-03-23

1990-05-08

Marcus, Michael S.

Surgery

Blood drawn and replaced or treated and returned to body

Constituent removed from blood and remainder returned to body

436 13, 436 71, 436 86, 604 5, G01N 3348

Patent

active

049234390

ABSTRACT:
Processes are described for the selective extracorporeal precipitation of low density lipoproteins or beta-lipoproteins from whole serum or plasma, wherein a treating agent comprising heparin or a polyanion, such as dextran sulfate or sodium-phosphorus tungstate, in a buffer is added to the whole serum or plasma and the beta-llipoprotein-complex which thereupon forms with the treating agent is precipitated at the isoelectric point at a pH value in the range of from about 5.05 to about 5.25, and is then separated. Optionally, the precipitate or respecively the filtrate is further analyzed for diagnostic purposes. When heparin is employed, the process may be employed therapeutically.
Apparatus is described for the continuous therapeutic practice of such a process, employing heparin, including means for flushing to reduce clogging of the filter employed to separate the precipitated lipoprotein-complex.

REFERENCES:
patent: 3955925 (1976-05-01), Proksch et al.
patent: 4103685 (1978-08-01), Lupien et al.
patent: 4110077 (1978-08-01), Klein et al.
patent: 4215993 (1980-08-01), Sanders
patent: 4264471 (1981-04-01), Briggs

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