Process for the selective chlorination of 4,5-dihydro-1-phenyl-1

Details Process for the selective chlorination of 4,5-dihydro-1-phenyl-1 Process for the selective chlorination of 4,5-dihydro-1-phenyl-1

1993-12-16

1995-11-21

Haley, Jacqueline

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D24912

Patent

active

054688680

ABSTRACT:
This invention provides a process for optimizing the yield of a 1-(2,4-dichlorophenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one by the chlorination in two steps of a 4,5-dihydro-1-phenyl-1H-1,2,4-triazol-5-one. The critical first step is the selective chlorination of the phenyl ring in the 4-position by addition of chlorine to a solution of the 4,5-dihydro-1-phenyl-1H-1,2,4-triazol-5-one in N,N-dimethylformamide. Chlorination of the product of the first step in acetic acid/water yields the 1-(2,4-dichlorophenyl)-4,5-dihydro-1H-1,2,4-triazol-5-one in high yield.

REFERENCES:
patent: 3591633 (1971-07-01), Ulrich
patent: 4818275 (1989-04-01), Theodoridis
patent: 4980480 (1990-12-01), Theodoridis
J. Am. Chem. Soc., 74, 3171 (1952) Adams & Braun.
J. Am. Chem. Soc., 74, 3033 (1952) Adams & Holmes.
Bull. Chem. Soc. Japan, 1970, 43(10), 3318 Seguchi et al.
J. Am. Chem. Soc., 83, 4605 (1961) Stock et al.
J. Am. Chem. Soc., 798, 4044 (1960), De La Mare et al.

Affiliated with

Also associated with

Rating

Process for the selective chlorination of 4,5-dihydro-1-phenyl-1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the selective chlorination of 4,5-dihydro-1-phenyl-1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the selective chlorination of 4,5-dihydro-1-phenyl-1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1138430