Process for the screening of cancer using nuclear magnetic reson

Details Process for the screening of cancer using nuclear magnetic reson Process for the screening of cancer using nuclear magnetic reson

1989-01-27

1990-03-27

Richman, Barry S.

Chemistry: analytical and immunological testing

Cancer

436 71, 436173, 324300, 324307, 324309, 128653A, G01N 3348

Patent

active

049120506

ABSTRACT:
A technique is disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are determined and compared against a corresponding value for healthy patients. In the preferred embodiments, an NMR spectrometer is employed in conjunction with a Fourier transformer to provide a spectrum for non-water components of blood, blood serum or blood plasma and the width of the methyl and/or methylene groups is measured at half-height as a determination of spin-spin relaxation time (T.sub.2) which is the parameter used for purposes of comparison with healthy controls. Suppression of the water proton signal is employed where necessary in order to obtain a suitable spectrum for the non-water component protons.

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