Process for the safe nitration of 2-methylimidazole

Details Process for the safe nitration of 2-methylimidazole Process for the safe nitration of 2-methylimidazole

1973-07-02

1980-06-24

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23392

Patent

active

042096316

ABSTRACT:
A method for the safe nitration of 2-methylimidazole with high output comprising nitrating the 2-methylimidazole with nitric acid and sulfuric acid as nitrating agents to produce 2-methyl-5-nitroimidazole, and controlling the reaction by adding as an inhibitor the reaction product itself or an excess of the concentrated nitric acid. The reaction can be carried out in stages with a reduced temperature in the first stage and an increased temperature in a subsequent stage.

REFERENCES:
patent: 3417091 (1968-12-01), Pickholz et al.
patent: 3631060 (1971-12-01), Sklarz et al.
patent: 3634446 (1972-01-01), Hoffer et al.
patent: 3666644 (1972-05-01), Kollonitsch et al.
Cosar et al., C.A. vol. 66: 2512x (1967).
Novikov et al., C.A. vol. 73: 66491z (1970).

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