Process for the resolution of racemic alpha-aminonitriles

Details Process for the resolution of racemic alpha-aminonitriles Process for the resolution of racemic alpha-aminonitriles

1978-03-30

1980-02-05

Brust, Joseph Paul

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465D, C07C12166

Patent

active

041872444

ABSTRACT:
Process for the resolution of certain racemic .alpha.-aminonitriles into optically active enantiomers which includes treating the racemic .alpha.-aminonitriles with (-)-mandelic acid in an alkanol/C.sub.5-8 hydrocarbon mixture to obtain a racemic mixture of diastereoisomeric D and L salts of (-)-mandelic acid, macerating the salts with an alkanol/C.sub.5-8 hydrocarbon mixture; neutralizing the L-form; extracting the neutralized product; and converting it into a stable form.

REFERENCES:
patent: 2906772 (1959-09-01), Weijlard
patent: 3344023 (1967-09-01), Reinhold et al.
patent: 3721697 (1973-03-01), Reinhold et al.
Stein et al., J.A.C.S., 77 (1955), pp. 700-703.

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