Process for the resolution of racemic .alpha.-aminonitriles

Details Process for the resolution of racemic .alpha.-aminonitriles Process for the resolution of racemic .alpha.-aminonitriles

1978-03-30

1980-01-15

Brust, Joseph Paul

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465D, C07C12166

Patent

active

041838653

ABSTRACT:
Process for the resolution of certain racemic .alpha.-aminonitriles into optically active enantiomers which includes treating the racemic .alpha.-aminonitriles with (-)-dibenzoyl-tartaric acid in polar solvents to obtain a racemic mixture of diastereoisomeric D and L salts of (-)-dibenzoyl-tartaric acid, macerating the salts with dioxane, neutralizing the L-form, extracting the neutralized product, and converting it into a stable form.

REFERENCES:
patent: 3344023 (1967-09-01), Reinhold et al.
patent: 3480670 (1969-11-01), Reinhold et al.
patent: 3658876 (1972-04-01), Reinhold et al.
patent: 3715382 (1973-02-01), Karaday et al.
patent: 3718674 (1973-02-01), Karaday et al.
patent: 3723496 (1973-03-01), Reinhold et al.
Stein et al., J.A.C.S., 77 (1955), pp. 700-703.

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