Process for the resolution of racemates using lactone esters

Details Process for the resolution of racemates using lactone esters Process for the resolution of racemates using lactone esters

1984-12-17

1989-08-08

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 43, 549285, 549305, 549314, 549318, 549461, 562401, 562402, C07D20982, C07D30791, C07D32100, C07B 5700

Patent

active

048554464

ABSTRACT:
Racemic carboxylic acids are resolved into their enantiomers using optically active enantiomers of four lactones as resolving agents. The four lactones are 2,3-isopropylidene-ribonic acid-1,4-lactone, 1,2-isopropylidene-glucofuranurono-3,6-lactone, 2-hydroxy-3,3-dimethyl-1,4-butyrolactone and 3,4-isopropylidene-arabino-1,5-lactone. Novel diastereoisomeric esters of the acids with the lactones are disclosed.

REFERENCES:
patent: 3185710 (1965-05-01), Dunkel et al.
patent: 4201874 (1980-05-01), Anderson et al.
patent: 4236026 (1980-12-01), Naumann
Chem Abstracts, vol. 70, paragraph 3199c (1969).
Organic Chemistry vol. II, 1968, FINAR, pp. 74-79.

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