Process for the resolution of ethyl 4,4,4-trifluoro-3(R)-hydroxy

Details Process for the resolution of ethyl 4,4,4-trifluoro-3(R)-hydroxy Process for the resolution of ethyl 4,4,4-trifluoro-3(R)-hydroxy

1996-04-05

1998-02-10

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

C12P 4100

Patent

active

057168415

ABSTRACT:
A process for the preparation of ethyl 4,4,4-trifluoro-3(R)-hydroxybutanoate, wherein the ester functional group of the (S) enantiomer of ethyl (.+-.)-4,4,4-trifluoro-3-hydroxybutanoate which comprises (R) and (S) is selectively hydrolysed in aqueous medium, by means of a lipase, and the non-hydrolysed (R) enantiomer is then extracted and used in the preparation of 4,4,4-trifluoro-1,3(R)-butanediol.

REFERENCES:
Lin et al., "A Microbially Based Approach for the preparation of Chiral Molecules Possessing the Trifluoromethyl Group", J. Org. Chem., vol. 52, No. 15 (1987) pp. 3211-3217.
Chemical Abstracts, vol. 116, No. 12, (1992), Abstract No. 127023d, p. 718, JP-A-03 254 694 (Kurita Water Ind.) 13 Nov. 1991.
Chemical Abstracts, vol. 113, No. 7, (1990) Abstract No. 57476r, p. 560, JP-A-02 040 343 (Meito Sangyo) Feb. 1990.
Chemical Abstracts, vol. 120, No. 3, (1994) Abstract No. 29497, Myazawa, Toshifumi et al. Microbial Manufacture of Optically Actiive Halogen-Containing Alcohols', JP-A-05 219 986.
Chem. Abstr., vol. 110, No. 13, (1989) Abstract No. 113136g, Kitazume, "A Microbially Based Approach for the Preparation of Fluorinated Ferroelectric Liquid Crystals".
Ehrler et al., "Noitz Uber Mikrobiologisch Umsetzungen Mit Halobacterium...." Helvetica Chimica Acta., vol. 72, No. 4, (1989) pp. 793-799.

Affiliated with

Also associated with

Rating

Process for the resolution of ethyl 4,4,4-trifluoro-3(R)-hydroxy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the resolution of ethyl 4,4,4-trifluoro-3(R)-hydroxy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the resolution of ethyl 4,4,4-trifluoro-3(R)-hydroxy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2076575