Process for the resolution of enantiomeric aryloxyphenoxy propio

Details Process for the resolution of enantiomeric aryloxyphenoxy propio Process for the resolution of enantiomeric aryloxyphenoxy propio

1987-08-05

1988-12-06

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 62, 71 94, 71109, 71116, 562401, 562472, C07D21172, C07B 5700, C07C 6760

Patent

active

047897449

ABSTRACT:
A process for the effective analytical or preparative resolution of the enantiomers of 2-(4-aryloxyphenoxy)propionic acids or the C.sub.1 -C.sub.4 alkyl esters thereof which comprises converting a racemic or partially resolved mixture of said 2-(4-aryloxyphenoxy)propionic acids or the C.sub.1 -C.sub.4 alkyl esters thereof to a pair of diastereomeric terpene esters by reaction with an optically active terpene alcohol and separating the diastereomers of the terpene ester by liquid chromatography with a silica column.

REFERENCES:
patent: 4531969 (1985-07-01), Nestler et al.
Wainer, Liquid Chromotography in Pharmaceutical Develop.; An Introduction, pp. 68-80, (1985).
Wainer, Chromatography Forum, 1, (4), pp. 55-61, (1986).
Souter, CRC Press, Boca Raton, Fla., pp. 50, 75, 81, 146 and 189, (1985).
Jiang et al., J. Chromatography, 248, pp. 143-149, (1982).
Guyon et al., J. Chromatography, 152, pp. 551-556, (1978).

Affiliated with

Also associated with

Rating

Process for the resolution of enantiomeric aryloxyphenoxy propio does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the resolution of enantiomeric aryloxyphenoxy propio, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the resolution of enantiomeric aryloxyphenoxy propio will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1494632