Process for the resolution of D,L-racemic mixtures

Details Process for the resolution of D,L-racemic mixtures Process for the resolution of D,L-racemic mixtures

1988-09-22

1989-09-05

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

558 48, 560 22, 562402, C07D23364, C07C 7946, C07B 6200

Patent

active

048640310

ABSTRACT:
The invention relates to a process for the kinetic resolution of D,L-racemic mixtures of racemates crystallizing as conglomerates. Resolution is effected from supersaturated solutions of these which is carried out in the presence of a polymer bound inhibitor of crystallization of the one form, resulting in the preferred crystallization of the one form, and when the other form is desired - in the presence of such inhibitor for the other form. Amongst racemic mixtures amenable to this process are amino acids. The process can be carried out in a two-compartment device, where the compartments are separated by a membrane which is permeable to the constituents of the racemate, while it is impervious to the polymer-bound inhibitor for the crystallization of one of the racemic forms.

REFERENCES:
patent: 2790001 (1957-04-01), Purvis
patent: 2937200 (1960-05-01), Fike
patent: 4533506 (1985-08-01), Lahav et al.
Addadi et al., J. Am. Chem. Soc., 104 4610, (1982).

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