Process for the resolution of certain octahydrobenzocycloheptapy

Details Process for the resolution of certain octahydrobenzocycloheptapy Process for the resolution of certain octahydrobenzocycloheptapy

1975-11-26

1977-12-13

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260286R, 260288CF, 260DIG8, C07D47106

Patent

active

040628515

ABSTRACT:
An efficient, commercially feasible process for the resolution of the organic bases, (.+-.)-(4a,13b-trans)-(3-hydroxy,13b-trans)-3-isopropyl-2,3,4,4a,8,9,13b,1 4-octahydro-1H-benzo[6,7]cyclohepta[1,2,-3-de)pyrido[2,1-a]isoquinolin-3-ol and (.+-.)-(4a,13b-trans)-(3-hydroxy,13b-trans)-3-tert-butyl-2,3,4,4a,8,9,13b, 14-octahydro-1H-benzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinolin-3-ol , known neuroleptic agents, is disclosed. The process comprises resolving the racemic organic bases with L-(+)-tartaric acid to obtain directly the pure L-(+) tartrate of the (+)-enantiomer and converting the latter salt to the corresponding (+)-enantiomer free base.

REFERENCES:
patent: 2545094 (1951-03-01), Long et al.
patent: 2545095 (1951-03-01), Long et al.
patent: 2680135 (1954-06-01), Gregory
patent: 3852452 (1974-12-01), Bruderlein et al.
patent: 3914305 (1975-10-01), Bruderlein et al.
patent: 3985751 (1976-10-01), Bruderlein et al.

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