Process for the resolution of (+)- and (-)-6-methoxy-.alpha.-met

Details Process for the resolution of (+)- and (-)-6-methoxy-.alpha.-met Process for the resolution of (+)- and (-)-6-methoxy-.alpha.-met

1979-07-06

1981-01-20

Evans, Joseph E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

562466, 562401, 564507, C07C 9110, C07C 6524, C07B 1900

Patent

active

042461642

ABSTRACT:
The subject of the invention is a process for resolving mixtures of (+)- and (-)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid into the enantiomers thereof, characterized in that N-methyl-D-glucamine [=1-deoxy-1-(methylamino)-D-glucitol] is used as the resolving agent, so that the 6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid is converted into the corresponding diastereoisomeric N-methyl-D-glucamine salt pair which, because of very different solubilities, can be separated easily and completely with high yield.

REFERENCES:
patent: 2016962 (1935-10-01), Flint et al.
patent: 2016963 (1935-10-01), Flint et al.
patent: 3904682 (1975-09-01), Fried et al.
patent: 3904683 (1975-09-01), Day et al.
patent: 3906038 (1975-09-01), Fried et al.
Greenstein et al., Chem. of the Amino Acids, John Wiley & Sons, Inc., N.Y. vol. 1, pp. 715-728 (1961).

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