Process for the resolution of 3-(4-substituted-phenyl)-glycidic

Details Process for the resolution of 3-(4-substituted-phenyl)-glycidic Process for the resolution of 3-(4-substituted-phenyl)-glycidic

1991-05-10

1993-03-30

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549539, 562401, 562402, 560 17, C07D30316, C07C32128

Patent

active

051985578

ABSTRACT:
A process for the kinetic resolution of cis or trans enantiomeric mixtures of the compounds of formula ##STR1## wherein R.sub.3 and X have the meanings reported in the specification and the asterisks mark the asymmetric carbon atoms, is described.
The compounds of formula III-A are intermediates useful in the preparation of compounds active on the cardiovascular system.

REFERENCES:
patent: 4931587 (1990-06-01), Piselli
patent: 4996352 (1991-02-01), Mohacsi
Merck Index, X Ed. No. 3189, p. 466.
Annual Drug Data Report, 1987, p. 507.
Protective Groups in Organic Synthesis, T. W. Green, Chapter 3, pp. 87-108.
J. Chem. Soc., Chem. Commun, 1990, vol (15), pp. 1018-1019 K. G. Watson et al., "Asymmetric Syntheses of (+) Diltiazem . . . ".

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