Process for the recovery of ampicillin

Details Process for the recovery of ampicillin Process for the recovery of ampicillin

1997-09-30

1999-06-29

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-4-aza-bicyclo

540317, 435 45, C12P 3704, C12P 3700, C07D49918, C07D49900

Patent

active

059167629

ABSTRACT:
Process for the recovery of ampicillin from a mixture containing ampicillin and 6-aminopenicillic acid (6-APA), in which a mixture of ampicillin and 6-APA, with a pH higher than 7, which apart from any solid ampicillin being present is homogeneous at a pH between 7 and 8.5, is subjected to a pH lowering till a pH lower than 8.2 is reached, and the solid substance present is recovered. The process is in particular suitable to be applied to the reaction mixture which is obtained after the enzymatic acylation reaction of 6-APA with a phenylglycidine derivative as acylation agent. Pure ampicillin can thus be recovered in a simple way.

REFERENCES:
patent: 3980637 (1976-09-01), Grossman et al.
patent: 4351766 (1982-09-01), Walker et al.
patent: 4354971 (1982-10-01), Edmundowicz et al.
patent: 5525483 (1996-06-01), Kaasgaard et al.
APS Japan Abstract 59-219291 Ishimaru et al, "Production of Antibiotic", Dec. 10, 1984.
Derwent ABS 95-075246/10 WO9503420 Boesten et al, "Recovery of D-Pheny-Glycine Amide from Antibiotic Coupling . . . ", Feb. 2, 1995.

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