Process for the recombinant production of ribonucleoproteins

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S071100, C435S252300, C435S320100, C536S023100, C536S023500, C530S350000

Reexamination Certificate

active

07122346

ABSTRACT:
A process is described for the recombinant production of ribonucleoproteins in prokaryotic cells.

REFERENCES:
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Pascal Bouffard et al., “Anti-Ro (SSA) Antibodies: Clinical Significance and Biological Relevance” The Journal of Rheumatology 1996: 23:11 pp. 1838-1841.
Susan L. Deutscher et al., “Molecular Analysis of the 60-kDa Human Ro Ribonucleoprotein” Proc. Natl. Acad. Sci. USA vol. 85, pp. 9479-9483, Dec. 1988 Biochemistry.
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A. Darise Farris et al., “Conserved Features of Y RNAs revealed by Automated Phylogenetic Secondary Structure Analysis” pp. 1070-1078 Nucleic Acids Research, 1999, vol. 27, No. 4, 1999 Oxford University Press.
D. Granger et al., “RNA-labelled Ro and La Ribonucleoprotein Complexes Ressembled in Vitro; Characterization by Gel Shift Analysis” Clin. Exp Immunol 1996: 106:498 503, 1996 Blackwell Science pp. 498-503.
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Jose Gerardo Garcia Lerma et al., “Evaluation of Recombinant Ro/SSA, La/SSB, Sm, and U1 RNP Autoantigens in Clinical Diagnosis” Journal of Clinical Laboratory Analysis 9:52-58 (1995) pp. 52-58.
E. William St. Clair et al., “Specificity of Autoantibodies for Recombinant 60-kd and 52-kd Ro Autoantigens” Arthritis & Rheumatism vol. 37, No. 9, Sep. 1994 pp. 1373-1379, 1994 American College of Rheumatology.
C.H.A. Veldhoven et al., “The Development of a Quantitative Assay for the Detection of Anti-Ro/SS-A and anti-LA/SS-B Autoantibodies using Purified Recombinant Proteins” Journal of Immunological Methods, 151 (1992) 177-189 1992 Elsevier Science Publishers B.V.
Dunrul Wang et al., “Cloning and Expression of Mouse 60 kDa Ribonucleoprotein SS-A/Ro” Molecular Biology Reports 23: 205-210, 1996.
Dong-Hai Wu et al., “A Simple Method for the Biochemical Purification of Ro/SS-A Antigen” Journal of Immunological Methods, 121 (1989) 219-224 Elsevier.
Arth. Rheum. 1997, vol. 40, 1750-1755 p. S323.

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