Process for the quantitative determination of prostate specific

Details Process for the quantitative determination of prostate specific Process for the quantitative determination of prostate specific

1993-10-13

1995-12-12

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 792, 435 794, 436518, 436 64, 436813, G01N 33574, G01N 3353

Patent

active

054749034

ABSTRACT:
The invention concerns a process for the quantitative determination of prostate specific antigen in a patient sample, with a predetermined weight or volume, through analysis. A patient sample undergoes a freeze concentration, is analyzed by standard quantitative analysis methods such as immunoassay techniques, and then the substance content is calculated back to the original sample volume or weight.

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Lange, P. H., et al. The value of Serum prostate specific antigen determinations before & after radical prostatectomy. Journal of Urology 141:873-879, 1989.
Tachibana, C. F. et al. High prevalence of e antigen among healthy blood donors carrying hepatitis B surface antigen in Japan. Vox Sang 32:296-299, 1977.
Tietz, N. W. Clinical Chemistry. Philadelphia: W B Saunders, 1986. pp. 27, 215-229.
Zubay, G. L., Biochemistry Reading, Mass: Addison-Wesley, 1983. pp. 478-479.
Graves, et al, "Ultrasensitive Radioimmunoassay fo Prostate Specific Antigen", Clinical Chemistry, vol. 38, No. 5, 1992, p. 735.
Graves, et al, "Comparison of a Polyclonal and Monoclonal Immunoassay for PSA: Need For An International Antigen Standard", The Journal of Urology, vol. 144, No. 6, Dec. 1990 p. 1516.

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