Process for the purification, solubilization and/or detoxificati

Details Process for the purification, solubilization and/or detoxificati Process for the purification, solubilization and/or detoxificati

1987-04-15

1988-09-27

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435243, 435244, 435253, 530417, A61K 3910, C07K 320

Patent

active

047740868

ABSTRACT:
A method for the purification, solubilization and/or detoxification of protein antigens of bacteria of the Bordetella genus involves the use of a carbonate buffer having a pH of 8.3 to 11.6. An acellular anti-whooping cough vaccine containing active principles in this carbonate buffer is also disclosed.

REFERENCES:
patent: 4247452 (1981-01-01), Irons et al.
patent: 4455297 (1984-06-01), Syukuda et al.
patent: 4500639 (1985-02-01), Suzuki et al.
patent: 4551429 (1985-11-01), Greenspan
patent: 4563303 (1986-01-01), Ginnaga et al.
patent: 4687738 (1987-08-01), Ginnaga et al.
patent: 4704274 (1987-11-01), Sakuma et al.
patent: 4705686 (1987-11-01), Scott et al.
Vaccine, vol. 3, (1985), Robinson et al., pp. 11-22.
The Lancet, Jan. 21, 1984, Sato et al., pp. 122-126.
Infection and Immunity, 41 (1983), Sato et al., pp. 313-320.

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