Process for the purification of ursodeoxycholic acid

Details Process for the purification of ursodeoxycholic acid Process for the purification of ursodeoxycholic acid

1980-07-11

1982-02-23

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 900

Patent

active

043168485

ABSTRACT:
A mixture of ursodeoxycholic acid and of chenodeoxycholic acid as well as of their salts and esters is reacted with a silylating agent in a suitable anhydrous organic solvent; the corresponding silyl-derivatives thus obtained are separated by crystallization and pure ursodeoxycholic acid is recovered from the corresponding silyl-derivatives in the usual manner.

REFERENCES:
patent: 3671555 (1972-06-01), Teichmuller et al.
patent: 3833620 (1974-09-01), Saltzman
patent: 3919266 (1975-11-01), Saltzman
Hisatsune et al., "Chem. Pharm. Bull.", No. 26, (9), (1978), pp. 2922-2923.
Karlaganis et al., "Clin. Chem. Act.", (1979), 92, pp. 19-26.
Chemical Abstracts 87, Pars. 85,166c, (1977).
Chemical Abstracts 87, Pars. 168,277r, (1977).
Chemical Abstracts 88, Pars. 148,367n, (1978).
Anal. Biochem., (1978), 85 No. 1, pp. 197/208.

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