Process for the purification of synthetic calcitonins

Details Process for the purification of synthetic calcitonins Process for the purification of synthetic calcitonins

1974-12-03

1976-04-06

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352, C07G 700, C08H 100

Patent

active

039488764

ABSTRACT:
Peptides of the calcitonin type when obtained by synthesis can be purified in a simple manner by forming inner salts, which precipitate from aqueous solutions of salts of the peptides with acids or bases when these solutions are adjusted to the isoelectric range. Impurities remain in solution, while the inner salts separate practically quantitatively. The precipitation is completed after several hours. The peptides can then be recuperated by treatment with an acid, especially a therapeutically suitable acid. The process affords products which are superior to those obtained by purification methods hitherto known and gives higher yields. Other long-chain peptides such as ACTH, insulin or glucagon cannot be purified in this manner.

REFERENCES:
patent: 3749703 (1973-07-01), Guttmann et al.
patent: 3775394 (1973-11-01), Arnaud
Tenenhouse et al., Proc. Nat. Acad. Sci., 53, pp. 818-822 (1965).
Tashjian et al., Am. J. Med., 43, pp. 668-677 (1967).

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