Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1

Details Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1 Process for the purification of (RR-SS)-2-dimethyl-aminomethyl-1

1996-11-14

1997-09-30

Burn, Brian M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564424, 564437, 564438, C07C20982

Patent

active

056727550

ABSTRACT:
The invention provides a process for the purification and isolation of (RR,SS)-2-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexanol from mixtures also containing the (RS,SR) isomer comprising reacting the above mixture in a solvent at elevated temperature under acidic conditions, whereby the (RS,SR) isomer is selectively converted to the (RR,SS) isomer, 1-(3-methoxyphenyl)-2-dimethylaminomethylcyclohex-6-ene, 1-(3-methoxyphenyl)-2-dimethyl-aminomethylcyclohex-1-ene or a mixture thereof, selectively precipitating the desired (RR,SS) isomer as an amine acid salt, and recrystallizing the purified product.

REFERENCES:
patent: 3652589 (1972-03-01), Flick
patent: 5414129 (1995-05-01), Cherkez

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