Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-01-04
2011-01-04
Chu, Yong (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07863462
ABSTRACT:
The present invention provides an improved process for the purification of ropinirole hydrochloride. The process includes (i) treating ropinirole hydrochloride with sodium dithionate and charcoal in suitable alcoholic solvent; (ii) triturating the ropinirole hydrochloride obtained in step (i) with ethanol; (iii) reacting the triturated solid with base in water immiscible solvent and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.
REFERENCES:
patent: 2005080333 (2005-09-01), None
patent: WO 2005080333 (2005-09-01), None
patent: 2005105741 (2005-11-01), None
4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone: A Prejunctional Dopamine Receptor Agonist; Gallagher, G., Jr., Lavanchy P, Wilson, J., Hieble, J, and DeMarinis R.; J. Med. Chem. 1985 vol. 28, pp. 1533-1536.
Syntheses and in Vitro Evaluation of 4-(2-Aminoethyl)-2(3H)-indolones and Related Compounds as Peripheral Prejunctional Dopamine Receptor Agonists; DeMarinis, R., Gallagher, G. Jr., Hall, R., Webster, C., Huffman, W., Schwart, M., Kaiser, C., Ross, S., Wilson, J., and Hieble, P.; J. Med. Chem. 1986, vol. 29, pp. 939-947.
Acharya Hitarth Harshendu
Deshpande Pandurang Balwant
Luthra Parven Kumar
Alembic Limited
Chu Yong
Volpe and Koenig P.C.
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