Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-06-28
2011-06-28
Chu, Yong (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07968731
ABSTRACT:
An improved process is described for the purification of ropinirole hydrochloride. The process includes (i) dissolving ropinirole hydrochloride in water; (ii) treating the solution obtained in step (i) with sodium dithionate and charcoal; (iii) treating the filtrate obtained in step (ii) with water immiscible solvent and base and isolating the free base; and (iv) treating the free base obtained in step (iii) with ethanolic HCl to give ropinirole hydrochloride.
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Gallagher et al., “4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone: A Prejunctional Dopamine Receptor Agonist”, J. Med. Chem., pp. 1533-1536, (1985).
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Acharya Hitarth Harshendu
Deshpande Pandurang Balwant
Luthra Parven Kumar
Shah Trushar Rajanikant
Shanishchara Ashok Prataprai
Alembic Limited
Chu Yong
Volpe and Koenig P.C.
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