Process for the purification of plasminogen activator inhibitor

Details Process for the purification of plasminogen activator inhibitor Process for the purification of plasminogen activator inhibitor

1992-06-02

1993-04-20

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435219, 435814, C12N 950, C12N 964

Patent

active

052042561

ABSTRACT:
A process for the purification of plasminogen activator inhibitor 2 (PAI-2) including the steps of preincubating a PAI-2-containing solution with a compound which cleaves disulfide linkages, mixing the solution with a water-soluble acridine or quinoline base to precipitate impurities in the solution, and separating the precipitated impurities to obtain PAI-2 in purified form.

REFERENCES:
patent: 4530787 (1985-07-01), Shaked et al.
patent: 4563417 (1986-01-01), Albarella et al.
patent: 4572798 (1986-02-01), Koths et al.
patent: 4677196 (1987-06-01), Rausch et al.
patent: 4892826 (1990-01-01), Homandberg et al.
patent: 4923807 (1990-05-01), Webb et al.
T. Stief et al., "Evidence for Identity of PCI and Plasminogen Activator Inhibitor 3", Biol. Chem. Hoppe-Seyler 368: 1427-1433 (1987).

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