Process for the purification of oligomers

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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528332, 424486, C12P 1934, C08G 6926

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active

058115382

ABSTRACT:
Methods for purifying an oligomer by normal phase column chromatography on a support selected from polyhydroxyethyl aspartamide, hydrophilic silica and silica from an oligomer impurity having a different nucleoside sequence are described. These methods are based upon the different retention times of the oligomer and the impurity on the column.

REFERENCES:
patent: 5342931 (1994-08-01), Woodard
Agrawal et al.,Chemical Abstracts, 113:317(2) abstract No. 128809q, Journal of Chromatography, 509:396ff(990) (see entire abstract).
Jerald L. Hoffman, J. Macromolecular Science and Chemistry, A7(5), pp. 1147-1157 (1973).

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